Pouchitis: what every gastroenterologist needs to know.
نویسنده
چکیده
Pouchitis is the most common complication among patients with ulcerative colitis who have undergone restorative proctocolectomy with ileal pouch-anal anastomosis. Pouchitis is actually a spectrum of diseases that vary in etiology, pathogenesis, phenotype, and clinical course. Although initial acute episodes typically respond to antibiotic therapy, patients can become dependent on antibiotics or develop refractory disease. Many factors contribute to the course of refractory pouchitis, such as the use of nonsteroidal anti-inflammatory drugs, infection with Clostridium difficile, pouch ischemia, or concurrent immune-mediated disorders. Identification of these secondary factors can help direct therapy.
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ورودعنوان ژورنال:
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
دوره 11 12 شماره
صفحات -
تاریخ انتشار 2013